EVALUATION OF THE EFFECT OF LOW-MOLECULAR CHITOSAN ON THE SOLUBILITY AND DISSOLUTION CHARACTERISTICS OF SPIRONOLACTONE


ACARTURK F., SENCAN A., CELEBI N.

PHARMAZIE, cilt.48, sa.8, ss.605-607, 1993 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Konu: 8
  • Basım Tarihi: 1993
  • Dergi Adı: PHARMAZIE
  • Sayfa Sayıları: ss.605-607

Özet

The effect of the low-molecular chitosan on the solubility and dissolution characteristics of spironolactone has been studied. Kneaded mixtures of spironolactone with low-molecular chitosan were prepared and their in vitro dissolution behaviours were examined. The interaction of spironolactone with low-molecular chitosan both in aqueous solution and in the solid state was examined by performing solubility analysis, powder X-ray diffractometry and differential scanning calorimetry measurements.