THE EFFECT OF BETA-CYCLODEXTRIN AND PENETRATION ADDITIVES ON THE RELEASE OF NAPROXEN FROM OINTMENT BASES

CELEBI N., KISLAL O., TARIMCI N.

PHARMAZIE, vol.48, no.12, pp.914-917, 1993 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 12
  • Publication Date: 1993
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.914-917
  • Gazi University Affiliated: No

Abstract

The in vitro release of naproxen (1) from various ointment bases; including gel base, University of California Hospital base (UCH) and water-washable emulsion base were studied. The effect of beta-cyclodextrin (beta-CD) and penetration additives (propylene glycol and dimethyl sulfoxide, DMSO) on the release rate of the drug were investigated.