Resveratrol' biotechnological applications: Enlightening its antimicrobial and antioxidant properties


Sharifi-Rad J., Quispe C., Durazzo A., Lucarini M., Souto E. B. , Santini A., ...More

JOURNAL OF HERBAL MEDICINE, vol.32, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 32
  • Publication Date: 2022
  • Doi Number: 10.1016/j.hermed.2022.100550
  • Journal Name: JOURNAL OF HERBAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, Veterinary Science Database
  • Keywords: Bioavailability, Biological effects, Nutraceuticals, Cosmeceuticals, Formulation, CELL-CYCLE PROGRESSION, TRANS-RESVERATROL, IN-VITRO, PHYTOALEXIN RESVERATROL, VITIS-VINIFERA, BIOACTIVE COMPOUNDS, MASS-SPECTROMETRY, HEALTH-BENEFITS, LIPID-BILAYERS, BIOAVAILABILITY
  • Gazi University Affiliated: Yes

Abstract

Introduction: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol obtained from diverse groups of plants, especially in the muscadine grape, red wine, lingonberry, cranberry and redcurrant. Resveratrol's health benefits were first highlighted in the study of the French paradox, which opened up an expansive research endeavor into this compound. Ever since, an array of pharmacological activities, including antioxidant, anti-aging, anti-inflammatory, anti-cancer and antidiabetic have been attributed to resveratrol. For many poly-phenols, low solubility in biological fluids, as well as by rapid in vivo metabolization, limits their bioavailability. However, improving resveratrol formulation could enhance oral bioavailability and have other beneficial properties. The development of innovative methodological approaches, such as the utilization of innovative formulations has been developed to overcome these limitations and provide a considerable therapeutic amount of resveratrol.Results: In this narrative review, a brief outline of historical perspectives of resveratrol is provided, together with an extensive and inclusive overview of various approaches and contemporary developments on the bioavail-ability, pharmacodynamics and pharmacokinetics of this nutraceutical, along with its biotechnological appli-cations and drug formulations.