ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population

ÖZBEY G., Yucel B., Taycan S. E., Kan D., Bodur N. E., Arslan T., ...Daha Fazla

PHARMACOLOGICAL REPORTS, cilt.66, sa.2, ss.235-238, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.pharep.2013.09.004
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.235-238
  • Anahtar Kelimeler: ABCB1, Polymorphism, Depression, Citalopram, Response, P-GLYCOPROTEIN GENE, MDR1 GENE, MULTIDRUG-RESISTANCE, IN-VITRO, BRAIN, PENETRATION, FREQUENCY, MICE, DISORDER, C1236T
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: The ATP-binding cassette sub-family B member 1 (ABCB1) gene, which encodes the p-glycoprotein at the blood-brain barrier, is investigated for patients' susceptibility to major depressive disorder (MDD) and their therapeutic response to antidepressants. However, there is an inconsistency between the studies of different ethnic groups. The current study aimed to determine the potential correlations of the ABCB1 gene C3435T polymorphism with the susceptibility to MDD and the therapeutic response to citalopram in a Turkish population.