Peritransplantation Acute Kidney Injury Has a Considerable Impact on Early Complications and Prognosis in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
International Journal of Clinical Practice, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/ijcp/2400549
- Dergi Adı: International Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: acute kidney injury, allogeneic stem cell transplantation, glomerular filtration rate, renal failure
- Gazi Üniversitesi Adresli: Evet
Özet
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment modality for a variety of hematological disorders. As baseline renal function is considered to have an essential role in the course of alloHSCT, it has been incorporated into pretransplantation scoring systems such as Sorror’s comorbidity index. The objective of this study was to assess the predictive factors that may influence the development of posttransplantation acute kidney injury (AKI), in accordance with the evaluation of the potential impact of AKI on transplantation outcome. Medical records of 434 alloHSCT recipients (median age: 44 [18–72] years; male/female: 259/175) were retrospectively reviewed. AKI was observed in a total of 316 patients (72.8%) in the first 100 days after alloHSCT. BK virus-associated cystitis (HR: 0.412, 95% CI: 0.193–0.882; p = 0.022), sepsis (HR: 2.329, 95% CI: 1.251–4.337; p = 0.008), and infused CD34+ cell count (HR: 1.698, 95% CI: 1.186–2.430; p = 0.004) were identified as independent predictive factors for the development of posttransplantation AKI. The probability of overall survival (OS) was substantially higher in Stage I AKI compared to Stage II/III (p = 0.03). Patients who had a higher eGFR on Day +30 had improved survival rates (p = 0.005). AKI may represent a frequent cause of morbidity in the early posttransplantation course. Considering its multifactorial etiology, management of potential predisposing issues may help to prevent associated complications and improve transplantation outcomes.