The new salt of 2-amino-3-methylpyridine with dipicolinic acid and its metal complexes: Synthesis, characterization and antimicrobial activity studies

İLKİMEN H., Salun S. G., GÜLBANDILAR A., SARI M.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1270, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1270
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.molstruc.2022.133961
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, INSPEC
  • Anahtar Kelimeler: 2-Amino-3-methylpyridine, Dipicolinic acid, Proton transfer salt, Metal complex, Antifungal, Antibacterial activity, PROTON-TRANSFER SALT, 2,6-PYRIDINEDICARBOXYLIC ACID, STRUCTURAL-CHARACTERIZATION, SILVER(I) COMPLEXES, CU(II) COMPLEXES, INHIBITION, CRYSTAL, PYRIDINE, 2-AMINO-6-SULFAMOYLBENZOTHIAZOLE, SPECTRA
  • Gazi Üniversitesi Adresli: Evet

Özet

A new proton transfer salt ( 3 ) synthesized from 2-amino-3-methyl pyridine with dipicolinic acid and its Fe(III) ( 4 ), Co(II) ( 5 ), Ni(II) and two Cu(II) ( 7 and 8 ) complexes were synthesized and characterized by NMR ( 1 H and 13 C), AAS, FT-IR, magnetic measurement, molar conductivity and UV. X-ray crystallography was performed to illuminate the structure of compounds 6 and 8 . Additionally, metal salts ( 9-12) , free compounds ( 1 and 2 ), simple metal complexes ( 13-20 ) of compounds 1 and 2 and synthesized com-pounds ( 3-8 ) have been assayed for their antimicrobial activities against Escherichia coli (ATCC 25,922) (Gram negative), Enterococcus faecalis (ATCC 29212) (Gram positive), Staphylococcus aureus (ATCC 29213) (Gram positive), Candida parapisilosis (ATCC 22019) (yeast), Candida albicans (ATCC 14053) (yeast) and Candida krusei (ATCC 6258) (yeast). Results of analyses were compared with Cefepime, Vancomycin and Levofloxacin (standard antibacterial agents) and Fluconazole (standard antifungal agents). Compounds with the best activity are 1, 3, 11, 16 and 17 (62.50) for E. Coli, 1, 11, 13 and 17 (31.25) for S. aureus, 11, 17 and 18 (31.25) for E. faecalis, 1, 3, 16 and 17 (31.25) for C. parapsilosis, 1 (15.60) for C. albicans and 1, 17, 18 and 20 (31.25) for C. krusei. Against all bacteria and yeasts, compound 17 had the highest activity (32.25) (except for C. albicans). (c) 2022 Elsevier B.V. All rights reserved.