Exogenous Ghrelin Enhances Endocrine and Exocrine Regeneration in Pancreatectomized Rats


KEREM M., Salman B., Ozsoy S., PAŞAOĞLU H., BEDİRLİ A., HAZIROĞLU R., ...More

JOURNAL OF GASTROINTESTINAL SURGERY, vol.13, no.4, pp.775-783, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1007/s11605-008-0778-2
  • Journal Name: JOURNAL OF GASTROINTESTINAL SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.775-783
  • Keywords: Pancreatectomy, Ghrelin, Regeneration, Pancreas, Type 3 diabetes, PANCREATIC BETA-CELLS, INSULIN-SECRETION, ISLET NEOGENESIS, INHIBIT APOPTOSIS, GLYCEMIC CONTROL, DIABETIC-RATS, ACTIVIN-A, EXPRESSION, BETACELLULIN, GROWTH
  • Gazi University Affiliated: Yes

Abstract

Ghrelin, the most important modulator of endocrine and exocrine pancreatic functions, has a role in the development of islets of Langerhans during embryogenesis. The aim of this study was to evaluate the effects of ghrelin on pancreatic regeneration in rats with 90% pancreatectomy.