Exogenous Ghrelin Enhances Endocrine and Exocrine Regeneration in Pancreatectomized Rats

KEREM M., Salman B., Ozsoy S., PAŞAOĞLU H., BEDİRLİ A., HAZIROĞLU R., ...Daha Fazla

JOURNAL OF GASTROINTESTINAL SURGERY, cilt.13, sa.4, ss.775-783, 2009 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11605-008-0778-2
  • Dergi Adı: JOURNAL OF GASTROINTESTINAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.775-783
  • Anahtar Kelimeler: Pancreatectomy, Ghrelin, Regeneration, Pancreas, Type 3 diabetes, PANCREATIC BETA-CELLS, INSULIN-SECRETION, ISLET NEOGENESIS, INHIBIT APOPTOSIS, GLYCEMIC CONTROL, DIABETIC-RATS, ACTIVIN-A, EXPRESSION, BETACELLULIN, GROWTH
  • Gazi Üniversitesi Adresli: Evet

Özet

Ghrelin, the most important modulator of endocrine and exocrine pancreatic functions, has a role in the development of islets of Langerhans during embryogenesis. The aim of this study was to evaluate the effects of ghrelin on pancreatic regeneration in rats with 90% pancreatectomy.