Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.28, sa.6, ss.811-821, 2008 (SCI-Expanded)
Objective: There have been great improvements in chromosome analysis software paralleling the developments in computer technology since 1980s. There are mainly three stages in generating karyotypes in chromosome analysis systems. These are 1. Capturing photography of the metaphase region by microscope using a video camera and saving it on a computer, 2. Eliminating the background noise by reducing the threshold value of the saved photography and differentiating the chromosomes, 3. Grouping each chromosome in the karyotype table according to their length and band structure. The purpose of using this method was to differentiate the normal and abnormal chromosomes with using the numerical data sequence and chart which obtain chromosomes photography. Meterial and Methods: In this study, chromosomes with inversions and normal chromosomes were compared with software. The software used in this study transforms the banded chromosome photograph to numeric data sequence. The numeric data sequence compared with Pearson Correlation analysis. Results: The software used in this study transforms the banded chromosome photograph to numeric data sequence. The resulting numeric data revealed the differences of chromosomes with normal and pathological structures using statistical analysis. Conclusion: Numeric data sequencing using a software program identified chromosomes without taking into account chromosome morphology. We suggest that the method described is beneficial in determining chromosome inversion and the classification of chromosomes. Copyright © 2008 by Türkiye Klinikleri.