Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder

Ertek İ. E., Uçar Ö., YAMAN M. E., EMMEZ Ö. H., CANDANSAYAR S.

Psychiatry and Clinical Psychopharmacology, vol.31, no.4, pp.401-407, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5152/pcp.2021.21223
  • Journal Name: Psychiatry and Clinical Psychopharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.401-407
  • Keywords: Anterior capsulotomy, Gamma Knife, obsessive-compulsive disorder, radiosurgery, treatment resistance, AGE-OF-ONSET, VENTRAL CAPSULOTOMY, DEPRESSION, COMORBIDITY, IMPACT, OCD
  • Gazi University Affiliated: Yes


© 2021, AVES. All rights reserved.Background: Obsessive-compulsive disorder (OCD) is a common disease that has negative effects on functionality, and 10% of the patients do not respond to first-line treatments. Gamma-knife radiosurgery (GKRS) has been used in patients with treatment-resistant OCD, but the data on long-term outcomes are still unsatisfactory. Methods: In this study, 12 patients who underwent GKRS between 2005 and 2020 were evaluated retrospectively. Anterior capsulotomy was performed using two 4-mm isocenters at the midputaminal point of the anterior limb of the internal capsule on each side with a maximum radiation dose of 140-180 Gy. Patients were followed up with the Yale-Brown Obsession and Compulsion Scale (Y-BOCS), Montgomery-Asberg Depression Rating Scale (MADRS), and Brief Psychiatric Rating Scale (BPRS) on the first, third, and sixth months. Results: After the procedure, a 35% reduction was observed in the overall Y-BOCS scores, and full response rate was 50%. There was a 49.5% decrease in the MADRS scores and a 57.8% decrease in the BPRS. Conclusion: GKRS is an effective and non-invasive procedure with favorable side effects in treatment-resistant OCD with selected patients.