Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E

APAYDIN F. G., Bas H., KALENDER S., KALENDER Y.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.49, ss.148-155, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.etap.2016.11.018
  • Dergi Adı: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.148-155
  • Anahtar Kelimeler: Bendiocarb, Vitamin C, Vitamin E, Liver toxicity, Oxidative stress, Histopathology, IN-VIVO, OXIDATIVE STRESS, PROTECTIVE ROLE, LIPID-PEROXIDATION, ANTIOXIDANT POWER, LEAD NITRATE, CHLORPYRIFOS, TISSUES, BLOOD, HEPATOTOXICITY
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8 mg/kg of body weight (bw), 100 mg/kg-bw and 100 mg/kg-bw for 28 days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone. (C) 2016 Elsevier B.V. All rights reserved.