Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts


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Gassman N. R. , Coskun E., Jaruga P., Dizdaroglu M., Wilson S. H.

ENVIRONMENTAL HEALTH PERSPECTIVES, cilt.124, sa.8, ss.1241-1252, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Konu: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1289/ehp237
  • Dergi Adı: ENVIRONMENTAL HEALTH PERSPECTIVES
  • Sayfa Sayıları: ss.1241-1252

Özet

BACKGROUND: Exposure to bisphenol A (BPA) has been reported to alter global gene expression, induce epigenetic modifications, and interfere with complex regulatory networks of cells. In addition to these reprogramming events, we have demonstrated that BPA exposure generates reactive oxygen species and promotes cellular survival when co-exposed with the oxidizing agent potassium bromate (KBrO3).