Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts


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Gassman N. R. , Coskun E., Jaruga P., Dizdaroglu M., Wilson S. H.

ENVIRONMENTAL HEALTH PERSPECTIVES, vol.124, no.8, pp.1241-1252, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 124 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1289/ehp237
  • Title of Journal : ENVIRONMENTAL HEALTH PERSPECTIVES
  • Page Numbers: pp.1241-1252

Abstract

BACKGROUND: Exposure to bisphenol A (BPA) has been reported to alter global gene expression, induce epigenetic modifications, and interfere with complex regulatory networks of cells. In addition to these reprogramming events, we have demonstrated that BPA exposure generates reactive oxygen species and promotes cellular survival when co-exposed with the oxidizing agent potassium bromate (KBrO3).