Changes in regional cerebral blood flow demonstrated by Tc-99m-HMPAO SPECT in euthymic bipolar patients

Culha A. F. , Osman O., Doganguen Y., Filiz K., Suna K., Kalkan O. N. , ...More

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, vol.258, no.3, pp.144-151, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 258 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s00406-007-0766-7
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.144-151


Single photon emission computed tomography (SPECT) with Tc-99m-HMPAO was used to compare regional cerebral blood flow (rCBF) in patients with bipolar disorder and in healthy controls. The sample of this study consisted of 16 euthymic bipolar patients who met the DSM-IV criteria and 10 healthy control subjects. The mean regional cerebral blood flow values of the bipolar euthymic patients were significantly lower than those of the controls in the bilateral medial-basal temporal, occipital; medial frontal; parietal regions and in the cingulate gyrus; the hypoperfusion in the cingulate had the highest significant P value (.001, Bonferroni correction). No significant differences in rCBF emerged between right and left-brain regions. The most important findings of the current study are the presence of regional cerebral perfusion alterations, particularly in the cingulate gyrus in the euthymic bipolar patients. Our results imply that underlying brain dysfunction may be independent from manic or depressive episodes in bipolar disorder. Because of the small number of subjects, however, this finding should be viewed as preliminary.