Oligemia, Penumbra, Infarction Understanding Hypoperfusion with Neuroimaging


Wu L., Wu W., TALI E. T. , Yuh W. T.

NEUROIMAGING CLINICS OF NORTH AMERICA, vol.28, no.4, pp.599-609, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1016/j.nic.2018.06.013
  • Title of Journal : NEUROIMAGING CLINICS OF NORTH AMERICA
  • Page Numbers: pp.599-609
  • Keywords: Acute ischemic stroke, Oligemia, Penumbra, Infarction, Hypoperfusion, Thrombolysis, Reperfusion, ACUTE ISCHEMIC-STROKE, TISSUE-PLASMINOGEN ACTIVATOR, PERFUSION-WEIGHTED MRI, COMPUTED-TOMOGRAPHY, INTRAARTERIAL TREATMENT, ENDOVASCULAR TREATMENT, PREDICTIVE-VALUE, BLOOD-PRESSURE, ASSOCIATION, THROMBOLYSIS

Abstract

Despite recent progress in the treatment of acute ischemic stroke with multiple trials demonstrating improved clinical outcome associated with endovascular thrombectomy up to 24 hours after onset, there is potential opportunity for optimal patient selection and treatment algorithm to further improve treatment outcome. Current limitation is in part caused by inconsistency of imaging protocols and imaging based definitions of oligemia, penumbra, and infarction core within the various hypo perfusion states. To truly maximize the impact of imaging in acute ischemic stroke, imaging definitions of hypoperfusion states need to be more consistent and validated to correctly reflect different severities of ischemic injury.