The increase of mean platelet volume in patients with Alzheimer disease


KOÇ E. R. , Uzar E., Cirak Y., Parlak Demir Y., Ilhan A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.44, no.6, pp.1060-1066, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.3906/sag-1212-5
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1060-1066
  • Keywords: Alzheimer disease, dementia, cognitive decline, mean platelet volume, platelet activation, vascular risk factors, AMYLOID PRECURSOR PROTEIN, VASCULAR RISK, ACTIVATION, MARKER, ASSOCIATION, PROGRESSION, DIAGNOSIS, AD

Abstract

Background/aim: Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors.