Synthesis and A Suggestion Mechanism on Biological Evaluation of Amino Acid-Schiff Base Ligands and Co(II), Cu(II) and Ni(II) Complexes

Koyuncu E. A., KARABOĞA M. N. S., Logoglu E., Sari N.

GAZI UNIVERSITY JOURNAL OF SCIENCE, cilt.29, sa.2, ss.303-307, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2016
  • Dergi Adı: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.303-307
  • Anahtar Kelimeler: Schiff base, Amino acid, Metal complexes, Antimicrobial activity, Radical, ZINC SUPEROXIDE-DISMUTASE, ANTIMICROBIAL ACTIVITY, HYDROGEN-PEROXIDE, CONDUCTIVITY, OXIDATION, COPPER, WATER
  • Gazi Üniversitesi Adresli: Evet

Özet

This study aimed to investigate of the antimicrobial activities of some amino acid-Schiff bases complexes as theoretical aspects. Co(II), Cu(II) and Ni(II) complexes of N, N'-(1,4-phenylenedimetiliden) bis DL-Alanine and N, N'-(1,4-phenylendimetiliden) bis DL-Glisine were been prepared and characterized. The antibacterial and antifungal activities were measured by Disc diffusion and MIC method against gram-positive bacteria i. e. Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium(clinical isolate), gram-negative bacteria Micrococcus Luteus NRRLB and as fungus Candida albicans. The antibiogram tests of amino acid-Schiff bases complexes showed better results than some known antibiotics. Especially Cu(II) complexes were more potent bacteridal than all of the substances synthesized. Furthermore a mechanism of reaction was offered in the explanation of these observation. Some of the compounds exhibited activity comparable to Ketoconazole, Ampicillin, Tetracycline, Penicillin, Gentamisin and Chloroamphenicol.