Synthesis and A Suggestion Mechanism on Biological Evaluation of Amino Acid-Schiff Base Ligands and Co(II), Cu(II) and Ni(II) Complexes

Koyuncu E. A., KARABOĞA M. N. S., Logoglu E., Sari N.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.29, no.2, pp.303-307, 2016 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2016
  • Journal Name: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.303-307
  • Keywords: Schiff base, Amino acid, Metal complexes, Antimicrobial activity, Radical, ZINC SUPEROXIDE-DISMUTASE, ANTIMICROBIAL ACTIVITY, HYDROGEN-PEROXIDE, CONDUCTIVITY, OXIDATION, COPPER, WATER
  • Gazi University Affiliated: Yes

Abstract

This study aimed to investigate of the antimicrobial activities of some amino acid-Schiff bases complexes as theoretical aspects. Co(II), Cu(II) and Ni(II) complexes of N, N'-(1,4-phenylenedimetiliden) bis DL-Alanine and N, N'-(1,4-phenylendimetiliden) bis DL-Glisine were been prepared and characterized. The antibacterial and antifungal activities were measured by Disc diffusion and MIC method against gram-positive bacteria i. e. Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium(clinical isolate), gram-negative bacteria Micrococcus Luteus NRRLB and as fungus Candida albicans. The antibiogram tests of amino acid-Schiff bases complexes showed better results than some known antibiotics. Especially Cu(II) complexes were more potent bacteridal than all of the substances synthesized. Furthermore a mechanism of reaction was offered in the explanation of these observation. Some of the compounds exhibited activity comparable to Ketoconazole, Ampicillin, Tetracycline, Penicillin, Gentamisin and Chloroamphenicol.