Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model

Lafci, Gokhan; Gedik, HİKMET; Korkmaz, Kemal; Erdem, Havva; Cicek, Omer; Nacar, Osman; Yildirim, Levent; Kaya, Ertugrul; ANKARALI, HANDAN

doi:10.1186/1749-8090-8-64

Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model

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Lafci G., Gedik H. S., Korkmaz K., Erdem H., Cicek O. F., Nacar O. A., ...More

JOURNAL OF CARDIOTHORACIC SURGERY, vol.8, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 8
Publication Date: 2013
Doi Number: 10.1186/1749-8090-8-64
Journal Name: JOURNAL OF CARDIOTHORACIC SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Gazi University Affiliated: No

Abstract

Background: The thoracic or thoracoabdominal aortic aneurysm surgery may cause spinal cord ischemia because of aortic cross-clamping and may result in severe postoperative complications caused by spinal cord injury. Ischemia/reperfusion injury may directly or indirectly be responsible for these complications. In this study we sought to determine whether combination of iloprost and montelukast can reduce the ischemia/reperfusion injury of spinal cord in a rat model.