Assessing autonomic nervous function by heart rate variability and heart rate turbulence in patients with acute ischemic stroke

Candemir M., Onder H.

ANNALS OF INDIAN ACADEMY OF NEUROLOGY, cilt.23, sa.5, ss.608-615, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4103/aian.aian_647_19
  • Dergi Adı: ANNALS OF INDIAN ACADEMY OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.608-615
  • Anahtar Kelimeler: Acute ischemic stroke, cardiac autonomic dysfunction, heart rate turbulence, heart rate variability, VENTRICULAR PREMATURE BEATS, CARDIAC EVENTS, MORTALITY, RISK, ARRHYTHMIAS, DYSFUNCTION, SYSTEM, DERANGEMENT, PREDICTORS, DISEASE
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Acute ischemic stroke (AIS) induces adverse effects on the cardiovascular system by affecting the autonomic nervous system (ANS). Objectives: This study aimed to determine whether the parameters of heart rate variability (HRV) and heart rate turbulence (HRT) differed in patients with AIS as compared to that in the control group. Furthermore, we aimed to determine the differences in the involvement of the ANS between right and left hemisphere (LH) strokes. Methods: A total of 148 [74 right hemispheres (RH) and 74 left hemispheres] patients with AIS and 80 control subjects were included in the study. The Holter device was used to obtain elcctrocardiogram readings for over 20 h from all patients. Results of HRV and HRT parameters [Tonset (TO) and Tslope (TS)] were acquired through an automatic analysis of the program. Results: All HRV parameters were found to be low in patients with AIS (P < 0.05, for all parameters). TO and TS were disrupted in 99 patients with AIS (66.8%) and in 15 control subjects (18.7%) (HRT-1 and HRT-2 groups, P = <0.001). HRV parameters were detected to be similar in patients, irrespective of the left or right infarct. TO and TS were normal in 31 patients (41.9%) with left hemisphere localization and in only 18 patients (24.3%) with right hemisphere localization. Conclusions: Combined evaluation of HRV and HRT parameters may provide important information regarding the alterations in the ANS in patients with AIS. The utility of HRT in the determination of ANS alterations in patients with AIS should be investigated in larger future prospective studies.