Starch-Based Membranes for Controlled Release of 5- Fluorouracil In Vitro

Berkkan A. , Kondolot Solak E. , Asman G.

CHEMISTRYSELECT, vol.6, pp.1-8, 2021 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 6
  • Publication Date: 2021
  • Doi Number: 10.1002/slct.202100917
  • Title of Journal : CHEMISTRYSELECT
  • Page Numbers: pp.1-8


Starch is a natural polymer that is among the sustainable

materials and has the characteristics of being a green material

in harmony with nature. In this study, a potential transdermal

release system was evaluated by investigating 5-fluorouracil (5-

FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes

in vitro. The effects of membrane thickness, starch/PVA

blending ratio, pH, and temperature on the release of 5-FU

from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount

of 5-FU from starch/PVA membranes and 5-FU transfer from

membranes could be controlled within a fairly constant range.

The diffusion coefficient was determined as 4.84�10􀀀 3, 4.49

�10􀀀 3 and 2.54�10􀀀 3 cm2 s􀀀 1 for the pH of 7.4, 5.5, and 3.5,

respectively. The activation energy for the permeation 5-FU

from starch/PVA membrane (60/40, v/v) was found to be

9.72 kJmol􀀀 1.