Starch is a natural polymer that is among the sustainable
materials and has the characteristics of being a green material
in harmony with nature. In this study, a potential transdermal
release system was evaluated by investigating 5-fluorouracil (5-
FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes
in vitro. The effects of membrane thickness, starch/PVA
blending ratio, pH, and temperature on the release of 5-FU
from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount
of 5-FU from starch/PVA membranes and 5-FU transfer from
membranes could be controlled within a fairly constant range.
The diffusion coefficient was determined as 4.84�10 3, 4.49
�10 3 and 2.54�10 3 cm2 s 1 for the pH of 7.4, 5.5, and 3.5,
respectively. The activation energy for the permeation 5-FU
from starch/PVA membrane (60/40, v/v) was found to be
9.72 kJmol 1.