Accumulation of an Endogenous Inhibitor of Nitric Oxide Synthesis and Oxidative DNA Damage in End-Stage Renal Disease

HACIŞEVKİ A., GÖNENÇ A., Sezer S., Karakan S., Simsek B., Torun M.

CLINICAL LABORATORY, vol.59, pp.1353-1361, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59
  • Publication Date: 2013
  • Doi Number: 10.7754/clin.lab.2013.121222
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1353-1361
  • Gazi University Affiliated: Yes


Background: Elevated oxidative status and reduced antioxidant defence systems in patients with chronic renal failure (CRF) accelerate the prevalence of atherosclerosis and other chronic complications. We aimed to investigate the levels of reactive oxygen, nitrogen species, and antioxidants in patients with end-stage renal disease (ESRD) having hemodialysis and controls and evaluate the factors that might influence the oxidative-antioxidative balance.