Synthesis and antimicrobial activities of unsymmetrical thioditetrazoles and their precursor thiotetrazoles

ÇAĞLAR TEKNİKEL Ö., ÖĞÜTCÜ H., DOYDUK D., DİŞLİ A.

ORGANIC COMMUNICATIONS, cilt.16, sa.4, ss.204-211, 2023 (ESCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.25135/acg.oc.158.2309.2893
  • Dergi Adı: ORGANIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.204-211
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).