Synthesis and antimicrobial activities of unsymmetrical thioditetrazoles and their precursor thiotetrazoles

Çağlar Teknikel Ö., Öğütçü H., Doyduk D., Dişli A.

ORGANIC COMMUNICATIONS, cilt.16, sa.4, ss.204-211, 2023 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.25135/acg.oc.158.2309.2893
  • Dergi Adı: ORGANIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.204-211
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).