Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction


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GÜNEŞ I., SÜNGÜ N., KILIÇARSLAN A., ŞIVGIN V., ALKAN M., KÜÇÜK A., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.12, pp.3061-3070, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2018
  • Doi Number: 10.2147/dddt.s165695
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3061-3070
  • Keywords: unilateral ureteral obstruction, hydroxyethyl starch solution 130/0.4, caspase 3, caspase 8, malondialdehyde, nitric oxide, OXIDATIVE STRESS, NITRIC-OXIDE, LIPID-PEROXIDATION, SEVERE SEPSIS, RENAL DAMAGE, APOPTOSIS, INJURY, FIBROSIS, SURGERY, BYPASS
  • Gazi University Affiliated: Yes

Abstract

Objective: This study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch (Voluven) on the kidney tissue of rats with late renal failure due to ureteral obstruction.