Antimicrobial activity and chemical composition of endemic Centaurea cariensis subsp niveo-tomentosa

UĞUR A., Sarac N., Ceylan O., Duru M. E.

NATURAL PRODUCT RESEARCH, vol.24, no.9, pp.861-872, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.1080/14786410903315127
  • Journal Name: NATURAL PRODUCT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.861-872
  • Keywords: Centaurea cariensis subsp, niveo-tomentosa, chemical composition, antimicrobial activity, GRAM-NEGATIVE BACTERIA, SESQUITERPENE LACTONES, STAPHYLOCOCCUS-AUREUS, TRADITIONAL MEDICINE, FOLK MEDICINE, ESSENTIAL OILS, SUSCEPTIBILITY, INFECTION, STRESS, TURKEY
  • Gazi University Affiliated: No

Abstract

The antimicrobial activity of the n-hexane, chloroform, ethyl acetate and ethyl alcohol extracts of the aerial parts of Centaurea cariensis subsp. niveo-tomentosa was evaluated against microorganisms, including multi-antibiotic resistant bacteria, using the paper disc diffusion method. The chemical composition of the chloroform extract of this plant was determined by gas chromatography and gas chromatography-mass spectrometry. The chloroform extract exhibited significant antibacterial activity for all bacteria tested, which are important pathogens. The major compounds of the chloroform extract were caryophyllene oxide (20.79%), spathulenol (14.73%), -eudesmol (9.27%), -caryophyllene (6.84%), n-cetylalcohol (6.27%), cubenol (5.23%) and cis--santalol (4.67%), respectively.