Effects of Thyroid Hormone on the Adaptation in Short Bowel Syndrome

YÜKSEL O., Tatlicioglu E., POYRAZ A., Sahin T., PAŞAOĞLU H., EKİNCİ Ö., ...More

JOURNAL OF SURGICAL RESEARCH, vol.155, no.1, pp.116-124, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.07.036
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.116-124
  • Keywords: short bowel syndrome, intestinal adaptation, thyroid hormone, transient hypothyroidism, INTESTINAL ALKALINE-PHOSPHATASE, ENTEROCYTE DIFFERENTIATION, GROWTH-FACTORS, RAT, GENE, CELL, RESECTION, HYPERTHYROIDISM, HYPOTHYROIDISM, ACTIVATION
  • Gazi University Affiliated: Yes

Abstract

Background. Thyroid hormone acts on structural and functional maturation of the mammalian small intestine, mitochondrial pathways, and several protein-gene interactions. Therefore, it is one of the most important regulators of intestinal epithelial differentiation. The aim of the study was to evaluate the effects of thyroid hormone on the adaptation in an experimental model of short bowel syndrome.