Development of a new real-time PCR screening kit for HbS and common beta-thalassemia mutations observed in Turkey

Kan Karaer D., ERGÜN M. A., ILGIN RUHİ H., Ozturk J., Kara H., Reisoglu Cakmak D., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.3, ss.973-978, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1606-49
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.973-978
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: IVSI-110 (G> A), IVSI-6 (T> C), IVSII-1 (G> A), IVSII-745 (C> G), IVSI-1 (G> A), and HbS are mutations covering 76% of all the beta-globin mutations in the Turkish population. In this study, our aim is to develop a reliable, fast, real-time kit for these mutations using the TaqMan probe method.