Development of a new real-time PCR screening kit for HbS and common beta-thalassemia mutations observed in Turkey


Kan Karaer D., ERGÜN M. A. , ILGIN RUHİ H., Ozturk J., Kara H., Reisoglu Cakmak D., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.47, sa.3, ss.973-978, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 47 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/sag-1606-49
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.973-978

Özet

Background/aim: IVSI-110 (G> A), IVSI-6 (T> C), IVSII-1 (G> A), IVSII-745 (C> G), IVSI-1 (G> A), and HbS are mutations covering 76% of all the beta-globin mutations in the Turkish population. In this study, our aim is to develop a reliable, fast, real-time kit for these mutations using the TaqMan probe method.