Effects of dexfenfluramine on serotonin levels of mice ileum, contractility, glutathione and malondialdehyde level.

Ozer Ç. , Gonul B., Elmas Ç. , Erdogan D., Ercan Z.

Molecular and cellular biochemistry, vol.280, pp.151-7, 2005 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 280
  • Publication Date: 2005
  • Doi Number: 10.1007/s11010-005-8842-7
  • Title of Journal : Molecular and cellular biochemistry
  • Page Numbers: pp.151-7


Dexfenfluramine is one of the anorectic drugs that suppresses food intake which acts via inhibition of reuptake of serotonin into brain terminal. Gastrointestinal tract is the main source of peripheral serotonin which is involved in the regulation of gastrointestinal motility. During the use of anorectic drugs, the antioxidant defence is affected especially by reactive oxygen species.