Heat pipe solar collectors (HPSCs) are heat exchangers that carry heat based on the phase change of the heat pipe working fluid. It is aimed to increase the operating temperature range of solar collectors by changing the phase of the working fluid in the heat pipe at low temperature. For this reason, it has become widespread to use nanofluids obtained by mixing nanosized metal oxides with the base fluid in certain proportions in order to increase both the thermal conductivity of the heat pipe working fluids and to increase the specific heat closures. The main purpose of this study, which was conducted to evaluate the performance of HPSCs, is to increase performance, and an experimental study has been conducted in this direction. For this purpose, an HPSC designed and manufactured was used. Al2O3-water and TiO2-water nanofluids containing 2% nanoparticles were used in order to increase performance in the study. HPSC used in the study consists of 8 heat pipes with a length of 100 cm. The experiments were carried out for pure water and nanofluids, and their efficiency and strength were compared. The highest value of instantaneous efficiency was calculated as 48% when pure water was used as the working fluid, 58% for Al2O3-water nanofluid, and 64% for TiO2-water nanofluid. The instantaneous power obtained using pure water was determined as 135.66 W, 167.96 W for Al2O3-water nanofluid, and 184.03 W for TiO2-water nanofluid. The improvement in efficiency was determined as 20.8% for Al2O3-water nanofluid and 33.3% for TiO2-water nanofluid. Improvement in powers was found to be 23.8% for Al2O3-water nanofluid and 35.6% for TiO2-water nanofluid.