Gabapentin suppresses cortical spreading depression susceptibility

Hoffmann U., Dilekoz E., Kudo C., Ayata C.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, cilt.30, sa.9, ss.1588-1592, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1038/jcbfm.2010.92
  • Dergi Adı: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1588-1592
  • Anahtar Kelimeler: cortex, electrophysiology, gabapentin, rat, spreading depression, CALCIUM-CHANNEL, BRAIN-INJURY, DEPOLARIZATIONS, DRUG, RATS, NEURONTIN, BLOCKADE, PLASMA
  • Gazi Üniversitesi Adresli: Evet

Özet

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1588-1592; doi:10.1038/jcbfm.2010.92; published online 30 June 2010