Role of G(s) proteins in hypoxic constriction of sheep pulmonary artery rings

Uzun O., Demiryurek A., Kanzik I.

PHARMACOLOGY, cilt.64, sa.4, ss.214-216, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 4
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1159/000056174
  • Dergi Adı: PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.214-216
  • Gazi Üniversitesi Adresli: Hayır

Özet

The introduction of hypoxia is well known to cause contraction of pulmonary artery rings in vitro. Despite intensive studies, the cellular mechanisms of hypoxic pulmonary vasoconstriction are still not well defined. In this study, we aimed to determine the contribution of G(S) proteins in hypoxia-induced vasoconstriction in large-diameter sheep pulmonary arteries using cholera toxin (CT). Hypoxia caused further contractions in serotonin but not in NaF-precontracted pulmonary artery rings. However, hypoxic vasoconstriction due to lowering Of pO(2) from 97 to 5 mm Hg was totally abolished by preincubation with CT in serotonin-precontracted arteries. These preliminary results indicate that signal transduction mediated by G(S) proteins may be an important mechanism in the hypoxic vasoconstriction of isolated pulmonary arteries of sheep. Copyright (C) 2002 S. Karger AG, Basel.