Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens

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Buyukafsar K., Levent A., Ark M.

BRITISH JOURNAL OF PHARMACOLOGY, cilt.140, sa.4, ss.743-749, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 140 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1038/sj.bjp.0705479
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.743-749
  • Anahtar Kelimeler: adenosine triphosphate, electrical field stimulation, fasudil, Rho kinase, Y-27632, vas deferens, MEDIATED CA2+ SENSITIZATION, SMOOTH-MUSCLE, MESENTERIC-ARTERIES, SIGNAL-TRANSDUCTION, URINARY-BLADDER, PROTEIN-KINASE, STIMULATION, INVOLVEMENT, INHIBITOR, Y-27632
  • Gazi Üniversitesi Adresli: Hayır

Özet

1 The effects of two Rho-kinase inhibitors, Y-27632 and fasudil, were investigated on the contractions produced by electrical field stimulation (EFS, 40 V, 1 mS, 2, 4, 8 and 16 Hz, for 20 s), KCl (30-60 mM), phenylephrine (Phe) (10(-5)-10(-4) M), adenosine-3', 5'-triphosphate (ATP) (10(-4)-10(-3) M) and alpha,beta-methylene ATP (10(-5) M).