Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens

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Buyukafsar K., Levent A., Ark M.

BRITISH JOURNAL OF PHARMACOLOGY, vol.140, no.4, pp.743-749, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 140 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1038/sj.bjp.0705479
  • Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.743-749
  • Keywords: adenosine triphosphate, electrical field stimulation, fasudil, Rho kinase, Y-27632, vas deferens, MEDIATED CA2+ SENSITIZATION, SMOOTH-MUSCLE, MESENTERIC-ARTERIES, SIGNAL-TRANSDUCTION, URINARY-BLADDER, PROTEIN-KINASE, STIMULATION, INVOLVEMENT, INHIBITOR, Y-27632
  • Gazi University Affiliated: No

Abstract

1 The effects of two Rho-kinase inhibitors, Y-27632 and fasudil, were investigated on the contractions produced by electrical field stimulation (EFS, 40 V, 1 mS, 2, 4, 8 and 16 Hz, for 20 s), KCl (30-60 mM), phenylephrine (Phe) (10(-5)-10(-4) M), adenosine-3', 5'-triphosphate (ATP) (10(-4)-10(-3) M) and alpha,beta-methylene ATP (10(-5) M).