EFFECT OF ALLOPURINOL ON MYOCARDIAL RECOVERY DURING REPERFUSION


SONCUL H., GOKGOZ L., KALAYCIOGLU S., SINCI V., KAPTANOGLU M., ERSOZ A.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, vol.53, no.1, pp.11-15, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 1
  • Publication Date: 1993
  • Doi Number: 10.3109/00365519309092526
  • Title of Journal : SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
  • Page Numbers: pp.11-15

Abstract

A comparative study on isolated guinea pig hearts was carried out to determine the effect of allopurinol added to reperfusion solution on myocardial recovery after global ischaemia. After 20 min of normothermic ischaemia two groups of solutions (1-Krebs Solution 2-Krebs Solution+Allopurinol 1 mmol l-1) were used for reperfusion (10 animals in each group). Post-ischaemic myocardial functions (ventricular contractile force and heart work) and enzyme activities (CK-MB, LD) were compared with their preischemic values.