High Performance Classification of Cancer Types with Gene Microarray Datasets: Hybrid Approach

Atay Y., Yıldırım M. O., Doğan C. U.

Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji, vol.9, no.4, pp.811-827, 2021 (Peer-Reviewed Journal)


Currently the approach of biological meaningfulness detection from gene microarray datasets obtained with microarray technology is used effectively in many areas such as disease diagnosis and differentiation of cancer types. However, since datasets obtained with this technology measure gene expression profiles collectively, the number of features in the dataset can be quite high. The small number of samples in gene microarray datasets, the high number of features and where the data is noisy significantly complicates the preparation process of these datasets. In order for machine learning models to successfully classify, the number of features that represent the size of the dataset should be reduced. In the proposed method, gene microarray data is taken as input and Information Gain, Fisher Correlation Scoring, ReliefF and, Chi-Square methods are applied separately for feature selection. After this stage, a sub-dataset containing the new genes is obtained and a pool of genes for Genetic Algorithm is created according to this dataset. Bayes classifier is trained using the sub-dataset created with the genes of the most successful chromosome. Thus, the classification process of cancer data is successfully completed. The model proposed in this study was applied to datasets that are frequently used in the literature and high success rates were obtained in classification. As a result; acceptable feature selection methods and the hybrid method based on Genetic Algorithm generally provided the most appropriate results on the all test data.