ASSOCIATION OF HLA CLASS-I AND CLASS-II ANTIGENS WITH RHEUMATIC-FEVER IN A TURKISH POPULATION

OLMEZ U., TURGAY M., OZENIRLER S., TUTKAK H., DUZGUN N., DUMAN M., ...Daha Fazla

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, cilt.22, sa.2, ss.49-52, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 1993
  • Doi Numarası: 10.3109/03009749309095114
  • Dergi Adı: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.49-52
  • Gazi Üniversitesi Adresli: Hayır

Özet

The distribution of class I and class II HLA antigens of 100 Turkish patients with rheumatic fever, 77 of whom had cardiac involvement, was examined. We compared the results with a control group of identical origin. The frequency of HLA A10 and HLA B35 antigens were found significantly higher in patients with rheumatic fever (p<0.05, p<0.01, respectively). The frequency of HLA A10 and HLA DRw11 in patients with cardiac involvement were significantly higher than in those without cardiac involvement (p<0.05, p<0.01, respectively). On the other hand, HLA Cw2 antigen frequency was found significantly higher in patients without cardiac involvement than in those with rheumatic heart disease (p<0.05). We support the concept that rheumatic fever is an immunological reaction to group A, beta hemolytic streptococci in individuals who have genetic predisposition.