Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic beta Cells

Rackova L., Cumaoglu A., BAĞRIAÇIK E. Ü., Stefek M., Maechler P., KARASU Ç.

MEDICINAL CHEMISTRY, vol.7, no.6, pp.711-717, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.2174/157340611797928370
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.711-717
  • Keywords: Indole antioxidant, pancreatic beta cells, oxidative stress, diabetes, INSULIN-PRODUCING CELLS, GLUCOSE TOXICITY, INDUCED APOPTOSIS, DEFENSE STATUS, MELATONIN, ANTIOXIDANT, STRESS, SECRETION, STREPTOZOTOCIN, METABOLISM
  • Gazi University Affiliated: Yes

Abstract

The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E beta cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.