Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic beta Cells

Rackova L., Cumaoglu A., BAĞRIAÇIK E. Ü. , Stefek M., Maechler P., KARASU Ç.

MEDICINAL CHEMISTRY, vol.7, no.6, pp.711-717, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 6
  • Publication Date: 2011
  • Doi Number: 10.2174/157340611797928370
  • Title of Journal : MEDICINAL CHEMISTRY
  • Page Numbers: pp.711-717


The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E beta cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.