Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic beta Cells
MEDICINAL CHEMISTRY, cilt.7, sa.6, ss.711-717, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 6
- Basım Tarihi: 2011
- Doi Numarası: 10.2174/157340611797928370
- Dergi Adı: MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.711-717
- Anahtar Kelimeler: Indole antioxidant, pancreatic beta cells, oxidative stress, diabetes, INSULIN-PRODUCING CELLS, GLUCOSE TOXICITY, INDUCED APOPTOSIS, DEFENSE STATUS, MELATONIN, ANTIOXIDANT, STRESS, SECRETION, STREPTOZOTOCIN, METABOLISM
- Gazi Üniversitesi Adresli: Evet
Özet
The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E beta cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.