Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic beta Cells

Rackova L., Cumaoglu A., BAĞRIAÇIK E. Ü., Stefek M., Maechler P., KARASU Ç.

MEDICINAL CHEMISTRY, cilt.7, sa.6, ss.711-717, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2174/157340611797928370
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.711-717
  • Anahtar Kelimeler: Indole antioxidant, pancreatic beta cells, oxidative stress, diabetes, INSULIN-PRODUCING CELLS, GLUCOSE TOXICITY, INDUCED APOPTOSIS, DEFENSE STATUS, MELATONIN, ANTIOXIDANT, STRESS, SECRETION, STREPTOZOTOCIN, METABOLISM
  • Gazi Üniversitesi Adresli: Evet

Özet

The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E beta cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.