Wound Healing Potential of Selected Liverworts Growing in Turkey

TOSUN A., SÜNTAR İ., KELEŞ H., ÖZENOĞLU KİREMİT H., Asakawa Y., Kuspeli Akkol E.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.13, no.3, pp.285-291, 2016 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.4274/tjps.2016.01
  • Journal Indexes: Emerging Sources Citation Index, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.285-291
  • Keywords: Wound healing, Liverworts, Bryophytes, Marchantiophyta, ETHNOPHARMACOLOGICAL SURVEY, MEDICINAL-PLANTS, CANCER, INDIA, RATS


The Bryophytes have been traditionally used to cure cuts, burns, external wounds, bacteriosis, pulmonary tuberculosis, neurasthenia, fractures, convulsions, scalds, uropathy, inflammation, fever and pneumonia. Selected eight liverworts growing in Turkey were tested for their wound healing potential. In the present study, in vivo wound-healing activities of the ethereal extracts of some liverworts collected from Southern Anatolia were investigated by using linear incision and circular excision experimental patterns subsequently histopathological analysis. For the bioassays, 1% ointment formulations were prepared from the crude extracts. The ethereal extracts from Reboulia hemisphaerica (L.) Raddi (Aytoniaceae), Plagiochasma rupestre (J.R. Forst et G.Forst) Steph. (Aytoniaceae), and Targionia hypophylla L. (Targioniaceae) showed 43.1, 38.3, and 24.1% increase in tensile strength on the linear incision wound test, respectively. The extracts of Reboulia hemisphaerica, Plagiochasma rupestre and Targionia hypophylla also exhibited significant contraction effect with the values of 62.1, 58.0, and 39.8%, respectively, on the circular excision wound model, quite comparable to reference sample. The liverworts have many important biological activities, which are investigated previously. However, the wound healing effects of Turkish liverworts have not been expounded yet. Thus, the results obtained from the present study will be important for the future researches. Moreover, the present study supported the usages of some Bryophytes in some native societies of the world against skin problems, including wound, bruises, burns, etc.