Neuroprotective Effects of Quercetin in Alzheimer's Disease

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Khan H., Ullah H., Aschner M., Cheang W. S., AKKOL E.

BIOMOLECULES, cilt.10, sa.1, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/biom10010059
  • Dergi Adı: BIOMOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: quercetin, polyphenols, Alzheimer's disease, mechanistic insights, clinical directions, O-METHYLATED ANALOGS, OXIDATIVE STRESS, RAT MODEL, COGNITIVE IMPAIRMENT, FLAVONOID QUERCETIN, DIETARY FLAVONOIDS, ANTIOXIDANT, ACETYLCHOLINESTERASE, EXTRACT, BRAIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-beta proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer's disease and its potential as a lead compound in clinical applications.