Anti-ulcerogenic lignans from Taxus baccata L.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.59, sa.3-4, ss.233-236, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 3-4
- Basım Tarihi: 2004
- Doi Numarası: 10.1515/znc-2004-3-420
- Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.233-236
- Anahtar Kelimeler: Taxus baccata, lignans, anti-ulcerogenic activity, CONSTITUENTS, TOXICITY
- Gazi Üniversitesi Adresli: Evet
Özet
Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-isolariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.