Anti-ulcerogenic lignans from Taxus baccata L.

Gurbuz İ., Erdemoglu N., Yesilada E., Sener B.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.59, sa.3-4, ss.233-236, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3-4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1515/znc-2004-3-420
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.233-236
  • Anahtar Kelimeler: Taxus baccata, lignans, anti-ulcerogenic activity, CONSTITUENTS, TOXICITY
  • Gazi Üniversitesi Adresli: Evet

Özet

Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-isolariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.