Anti-ulcerogenic lignans from Taxus baccata L.

Gurbuz İ., Erdemoglu N., Yesilada E., Sener B.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol.59, no.3-4, pp.233-236, 2004 (SCI-Expanded) identifier identifier identifier


Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-isolariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.