Quantitative determination of Fluconazole in capsules and IV solutions by UV spectrophotometric methods

Goger N., Aboul-Enein H.

ANALYTICAL LETTERS, cilt.34, sa.12, ss.2089-2098, 2001 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 12
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1081/al-100106841
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2089-2098
  • Gazi Üniversitesi Adresli: Evet

Özet

Quantitative determination of Fluconazole in IV solutions was carried out by UV spectrophotometric method using the absorbance values at 261.6 nm and the second order derivative absorbance values at 274 nm. Distilled water was used as solvent throughout the study. The concentration range was 4.0 x 10(-4)-1.5 x 10(-3) M for the two spectrophotometric methods. While detection limit was 4.37 mug/mL in direct UV method. it was 2.63 mug/mL in derivative spectrophotometric method.