Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation


Cevizci R., DÜZLÜ M. , DÜNDAR Y. , Noyanalpan N., Sultan N., TUTAR H. , ...More

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.272, no.6, pp.1389-1393, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 272 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1007/s00405-014-2942-5
  • Title of Journal : EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Page Numbers: pp.1389-1393
  • Keywords: Biofilm, Quorum sensing, Cochlear implant infection, BACTERIAL BIOFILMS, MANAGEMENT

Abstract

The purpose of the study is to assess the effect of a novel quorum sensing inhibitor (QSI), coded as 'yd 47', against otitis media and biofilm formation on Cochlear implants (CIs). Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs. The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline, respectively. The right and left middle ears were also instilled with a solution containing pneumococci and saline, respectively. The animals were only given an intraperitoneal 'yd 47' twice daily for three months to be assessed later with electron microscopy. Clinical examination with palpation, inspection and otoscopy did not reveal any sign of implant infection or otitis media. In the study and control implant materials, soft tissues around the implant and tympanic membranes, there was no biofilm formation by pneumococci. Contamination by various cells and some rod-shaped bacteria (not diplococcic) were seen in some of the materials. In conclusion, the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci.