Chronic bullous disease of childhood in a patient with acute lymphoblastic leukemia - Possible induction by a drug

Polat M., Lenk N., Kurekci E., Oztas P., Artuz F., Alli N.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, vol.8, no.6, pp.389-391, 2007 (SCI-Expanded) identifier identifier identifier


Linear IgA disease is characterized by the presence of linear IgA deposits in the basement membrane zone of the skin, and circulating basement membrane zone antibodies are detected in 80% of cases. The disease occurs in both adults and children, and is designated adult linear IgA disease in the former and chronic bullous disease of childhood (CBDC) in the latter. We describe a 5-year-old boy with acute lymphoblastic leukemia in remission, in whom CBDC developed after treatment with trimethoprim/sulfamethoxazole (cotrimoxazole). To our knowledge, this is the first reported case of possible drug-induced CBDC.