ICMATSE 2020 International Conference On Advanced Materials Science & Engineering And High Tech Device Applications, 2 - 04 Ekim 2020, ss.48-49
Nanoparticles (NPs) and nanoparticle-based materials have been increasingly used in different consumer and medical applications. Although some NPs are specifically produced to induce special cytotoxicity for targeting microorganisms or cancerous cells, other NPs were produced to compatible with the biological systems they applied without adverse effects. However, studies have demonstrated that some nanoparticles have cytotoxic and genotoxic effects in different cell types and organisms. In this study, cytotoxic and genotoxic potential of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles were examined by using chromosome aberrations (CAs), sister chromatid exchange (SCE), micronucleus (MN), and comet assays in human lymphocytes in vitro. The results showed that TiO2 NPs have a relatively weak genotoxic effect, in contrast, ZnO NPs have a strong genotoxic effect as well as a cytotoxic effect at high concentrations. Owing to the chance of exposure for workers, consumers, and the environment, investigating the toxic impacts of NPs are very important not only for their risk assessment but also for safe-by-design technologies to avoid or diminish some of their adverse effects to living things.