SYNERGISM BETWEEN UK 38485 AND ICI 185282 AGAINST DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS


KANZIK I., ZENGIL H., IPEK N., CAKICI I., ABACIOGLU N., DORTLEMEZ H.

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, vol.312, pp.55-65, 1991 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 312
  • Publication Date: 1991
  • Title of Journal : ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
  • Page Numbers: pp.55-65

Abstract

In this study, the combination of a thromboxane synthetase inhibitor (UK 38 485) and a thromboxane receptor antagonist (ICI 185 282) was tested for an interaction of potential therapeutic importance and the effect of acetylsalicylic acid pretreatment on this combination was evaluated in digoxin-induced arrhythmias in guinea-pigs. Drug treatments at the dose combinations used (ICI 185 282: 0.2 mg/kg + 0.2 mg/kg/hr + UK 38 485 0.1 mg/kg/hr and ICI 185 282: 2 mg/kg + 2 mg/kg/hr + UK 38 485 1 mg/kg/hr) markedly reduced the incidence of ventricular fibrillation, mortality rate and arrhythmia score. Pretreatment with acetylsalicylic acid plus drug combination resulted in a dose-dependent increase in mortality rate and arrhythmia score.