Consequences of hypoxia-reoxygenation phenomena in patients with obstructive sleep apnea syndrome

ULUKAVAK ÇİFTÇİ T., KÖKTÜRK O., Demirtas S., GÜLBAHAR Ö., BUKAN N.

ANNALS OF SAUDI MEDICINE, vol.31, no.1, pp.14-18, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.4103/0256-4947.75772
  • Journal Name: ANNALS OF SAUDI MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.14-18
  • Gazi University Affiliated: Yes

Abstract

BACKGROUND AND OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by numerous episodes of absence of respiratory flow during sleep, which can be followed by a decrease in SaO(2), which is rapidly normalized when ventilation resumes. We hypothesize that this hypoxia-reoxygenation phenomena may affect the generation of vascular endothelial growth factor (VEGF), erythropoietin (EPO), endothelin-1 (ENDO-1), and inducible nitric oxide synthase (iNOS).