E-Cadherin Expression in Endometrial Malignancies: Comparison between Endometrioid and Non-endometrioid Carcinomas

Yalta T., ATAY L. Ö., Atalay F., Caydere M., Gonultas M., Ustun H.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.37, sa.1, ss.163-168, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1177/147323000903700119
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.163-168
  • Anahtar Kelimeler: E-CADHERIN, ENDOMETRIOID CARCINOMA, NON-ENDOMETRIOID CARCINOMA, CANCER CELL-LINE, BETA-CATENIN, GENE, INVASION, TUMORS, WOMEN
  • Gazi Üniversitesi Adresli: Evet

Özet

This study examined the frequency of E-cadherin expression in endometrial biopsy or hysterectomy specimens from patients diagnosed with endometrial adenocarcinoma and in normal endometrial tissue specimens. E-cadherin expression was detected by immunohistochemistry using monoclonal antibody to E-cadherin. Specimens were classified as positive when >= 5% of the tumour cells showed staining for E-cadherin, irrespective of the pattern of staining. Twenty-three endometrioid carcinomas and nine non-endometrioid (four papillary serous and five clear cell) carcinomas were studied, along with 10 normal endometrial tissue specimens as controls. E-cadherin expression was significantly less frequent in non-endometrioid carcinomas compared with endometrioid carcinomas and controls. There was no statistically significant difference in the frequency of E-cadherin expression between endometrioid carcinomas and controls. In conclusion, this study demonstrated that uterine non-endometrioid (papillary serous and clear cell) carcinomas were less likely to express E-cadherin compared with endometrioid carcinomas and normal endometrial tissue. This may help to explain the more aggressive behaviour of non-endometrioid carcinomas.