Sulfasalazine decreases acute gastrointestinal complications due to pelvic radiotherapy


Kilic D., Ozenirler S., Egehan I., Dursun A.

ANNALS OF PHARMACOTHERAPY, vol.35, pp.806-810, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35
  • Publication Date: 2001
  • Doi Number: 10.1345/aph.10055
  • Title of Journal : ANNALS OF PHARMACOTHERAPY
  • Page Numbers: pp.806-810

Abstract

BACKGROUND: Radiation-induced gastrointestinal toxicity is a significant concern for patients who are treated with this modality for pelvic malignancies. Eicosanoids and free radicals are thought to be among the reasons for this effect. Sulfasalazine is an inhibitor of their synthesis in the mucosa.