Sulfasalazine decreases acute gastrointestinal complications due to pelvic radiotherapy


Kilic D., Ozenirler S., Egehan I., Dursun A.

ANNALS OF PHARMACOTHERAPY, vol.35, pp.806-810, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35
  • Publication Date: 2001
  • Doi Number: 10.1345/aph.10055
  • Journal Name: ANNALS OF PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.806-810

Abstract

BACKGROUND: Radiation-induced gastrointestinal toxicity is a significant concern for patients who are treated with this modality for pelvic malignancies. Eicosanoids and free radicals are thought to be among the reasons for this effect. Sulfasalazine is an inhibitor of their synthesis in the mucosa.