Hypoxia-related molecules HIF-1α, CA9, and osteopontin Predictors of survival in patients with high-grade glioma

Erpolat Ö. P., Gocun P. U., Akmansu M., Ozgun G., Akyol G.

STRAHLENTHERAPIE UND ONKOLOGIE, no.2, pp.147-154, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2013
  • Doi Number: 10.1007/s00066-012-0262-5
  • Journal Name: STRAHLENTHERAPIE UND ONKOLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.147-154
  • Keywords: High-grade glioma, Hypoxia, Osteopontin, Survival, Prognostic factors, INDUCIBLE FACTOR-1, TUMOR HYPOXIA, EXPRESSION, ANGIOGENESIS, GLIOBLASTOMA, BRAIN, OVEREXPRESSION, IDENTIFICATION, BIOMARKERS, PROGNOSIS
  • Gazi University Affiliated: Yes

Abstract

A high expression of hypoxia-inducible factor-1 alpha (HIF)-1 alpha, carbonic anhydrase 9 (CA9), aontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas. HIF-1 alpha, CA9, and osteopontin levels in tissue specimens of 92 patients with high-grade glioma were evaluated by immunohistochemistry. Patients with a high expression of cytoplasmic and nuclear HIF-1 alpha, CA9, and osteopontin had significantly shorter overall survival. The expression results of these markers were combined to form a hypoxic profile, and high hypoxic scores (expression of two or three markers) were significantly correlated to poorer overall survival. In multivariate analysis, high hypoxic score-1 (cytoplasmic HIF-1 alpha, CA9, and osteopontin) was the only independent negative prognostic factor for survival (p = 0.028). Our results showed that a combination of hypoxic markers is more robust than a single marker for predicting survival in high-grade glioma. It may be necessary to utilize the hypoxic score in selecting patients for targeted therapy in the future.