Effects of Picroside II on Myocardial Ischemia-Reperfusion Injury in Streptozotocin-Induced Diabetic Rats


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Polat Y., DURSUN A. D. , KÜÇÜK A., ÖZER A., ERER D., ARSLAN M.

GAZI MEDICAL JOURNAL, vol.28, no.1, pp.27-30, 2017 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.12996/gmj.2017.07
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.27-30
  • Keywords: Ischemia-reperfusion, total oxidant status, total antioxidant status, picroside II, myocardial tissue, rat, TOLL-LIKE-RECEPTORS, LIPID-PEROXIDATION, PICRORHIZA-KURROA, RENAL INJURY, T-CELLS, ILOPROST, MODULATION, EXPRESSION, OXYGEN, LIVER

Abstract

Objective: Diabates mellitus, is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischemia-reperfusion injury is a cascade of events initiated by tissue ischemia. The cellular damage produced by reperfusion leads to an active inflammatory response. This study was performed to investigate the effect of picroside II on myocardial ischemiareperfusion injury in rats with streptozotocin-induced diabetes.