Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

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Özçelik B., Kartal M., Erdoğan Orhan İ.

PHARMACEUTICAL BIOLOGY, cilt.49, sa.4, ss.396-402, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/13880209.2010.519390
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.396-402
  • Anahtar Kelimeler: Alkaloids, antimicrobial activity, antiviral activity, flavonoids, herpes simplex, parainfluenza, phenolic acids, HERPES-SIMPLEX VIRUSES, MEDICINAL-PLANTS, IN-VITRO, EXTRACTS, SILYMARIN, TYPE-1, ANTIBACTERIAL, ISOQUINOLINE, ANTIFUNGAL, HEPATITIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.