Pattern of disease onset, diagnostic delay, and clinical features in juvenile onset and adult onset ankylosing spondylitis

Ozgocmen S., Ardicoglu O., Kamanli A., Kaya A., Durmus B., Yildirim K., ...Daha Fazla

Journal of Rheumatology, cilt.36, sa.12, ss.2830-2833, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 12
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3899/jrheum.090435
  • Dergi Adı: Journal of Rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2830-2833
  • Anahtar Kelimeler: Adult onset, Ankylosing spondylitis, Diagnostic delay, Juvenile onset
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective. To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design. Methods. A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Turkey. Results. Patients with JOAS (n = 43, 13.4%) had significantly longer diagnostic delay (9.21 vs 5.08 yrs), less severe axial involvement and more prevalent uveitis (OR 2.92, 95% CI 1.25-6.79), and peripheral involvement at onset (OR 3.25, 95% CI 1.51-6.98, adjusted for current age; and OR 2.26, 95% CI 1.07-4.76, adjusted for disease duration). Patients with AOAS had higher radiographic scores and more restricted clinimetrics but similar functional limitations and quality of life. Conclusion. JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient populations. The Journal of Rheumatology Copyright © 2009. All rights reserved.