Akademik Veri Yönetim Sistemi
Mustansiriya Medical Journal, cilt.20, ss.76-81, 2021 (Hakemli Dergi)
Backgroud: Type 2 diabetes mellitus (DM2) is a metabolic disease resulting from the genetic and environmental factors and which causes
insulin dysfunction on peripheral tissues, as well as in the pancreatic β‑cell. Underlying pathologies such as overweight and obesity are the
main factors for the development of T2DM. Interleukin‑37 (IL‑37) is an anti‑inflammatory cytokine and also called as a “dual function.”
Aim of study: This study has demonstrated was elevated in the obese T2DM patients and IL‑37 protects from obesity‑induced leading to
development of T2DM. Fifty‑eight patients who visited to the National Center for Diabetes Research and Treatment in the İraq/Baghdad with
the age of <40–>60 years were employed in this study. Patient groups were 29 obese T2DM and 29 nonobese T2DM patients, and they when
compared with 29 individuals as healthy control groups. In this study, serum IL‑37 levels were determined by enzyme linked immunosorbent
assay. Results: In obese T2DM patients, the mean serum level of IL‑37 was elevated and significantly higher (mean ± standard deviation [SD],
5.594 ± 3.421 pg/ml; P < 0.0001) in comparison with nonobese T2DM patients (mean ± SD, 1.851 ± 0.417 pg/ml; P < 0.0001) and healthy
control group (mean ± SD, 0.777 ± 0.099 pg/ml). Conclusions: In this study, obese T2DM patients had higher serum IL‑37 levels but lower
serum IL‑37 levels in nonobese diabetic patients as compared to the healthy controls. This result led to the supposition that the rise in serum
IL‑37 level is related with obesity. Further, it suggests that IL‑37 being an anti‑inflammatory mediator might be responsible for some underline
changes, which may develop the progress of T2DM.
Keywords: Interleukin‑37, obesity, type 2 diabetes mellitus