Neuroprotective effect of topically applied brimonidine tartrate 0.2% in endothelin-1-induced optic nerve ischaemia model

Aktas Z., Goerelik G., Akyuerek N., Oenol M., Hasanreisoglu B.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.35, sa.6, ss.527-534, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1442-9071.2007.01533.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.527-534
  • Anahtar Kelimeler: brimonidine tartrate 0.2%, endothelin-1, neuroprotection, optic nerve ischaemia, RETINAL GANGLION-CELLS, IN-VIVO, GLAUCOMA, APOPTOSIS, SECTIONS, AGONISTS, RABBITS, DAMAGE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background: To investigate the neuroprotective effects of topically applied brimonidine tartrate 0.2% (BMD), an alpha(2)-receptor agonist, on the retinal ganglion cell (RGC) layer and inner nuclear layer (INL) of rabbit retina in endothelin-1 (ET-1)-induced optic nerve (ON) ischaemia model.